Do not use if you have unusual vaginal bleeding, have or have had breast cancer or another estrogen-dependent cancer, have had a stroke, heart attack or blood clots, have liver problems or a bleeding disorder, are allergic to any ingredient, or are pregnant. Children and pets can be exposed to estradiol by touching sprayed skin: let it dry, cover the area with clothing if contact is likely, and tell your clinician if a child shows breast changes or a pet shows signs of exposure. The spray is flammable until dry; avoid fire, flame and smoking while applying. Common side effects include headache, breast tenderness, nausea and irregular bleeding or spotting. Seek emergency care for chest pain, shortness of breath, sudden severe headache, vision changes, or pain or swelling in the legs.